VDR Gene (Vitamin D Receptor) | FuelYourDNA

About this gene

Nuclear receptor that mediates vitamin D effects on calcium absorption and bone health

Regulates calcium and phosphorus absorption, bone metabolism, and immune function

rs731236 TaqI Population frequency: 40.0%

VDR variant influencing bone mineral density

Genotype	Impact	What it means
TT (Normal)	Normal	Normal vitamin D receptor function and calcium absorption.
TC (Carrier)	Low impact	Slightly reduced vitamin D receptor sensitivity. May benefit from higher vitamin D intake.
CC (Variant)	Moderate	Reduced vitamin D receptor sensitivity. Higher vitamin D intake recommended (2000-4000 IU/day).

rs7975232 VDR ApaI Population frequency: 45.0%

Genotype	Impact	What it means
CC (Normal)	Normal	Normal vitamin D receptor function and calcium absorption.
CA (Carrier)	Low impact	Slightly reduced vitamin D receptor sensitivity. May benefit from higher vitamin D intake.
AA (Variant)	Moderate	Reduced vitamin D receptor sensitivity. Higher vitamin D intake recommended (2000-4000 IU/day).

rs1544410 BsmI Population frequency: 42.0% Chr. 12 : 48,239,835

VDR variant affecting vitamin D receptor sensitivity

Genotype	Impact	What it means
GG (Normal)	Normal	Normal vitamin D receptor function and calcium absorption.
GA (Carrier)	Low impact	Slightly reduced vitamin D receptor sensitivity. May benefit from higher vitamin D intake.
AA (Variant)	Moderate	Reduced vitamin D receptor sensitivity. Higher vitamin D intake recommended (2000-4000 IU/day).

rs2228570 FokI Population frequency: 40.0% Chr. 12 : 48,272,895

VDR variant affecting receptor translation start

Genotype	Impact	What it means
CC (Normal)	Normal	Normal vitamin D receptor function and calcium absorption.
CT (Carrier)	Low impact	Slightly reduced vitamin D receptor sensitivity. May benefit from higher vitamin D intake.
TT (Variant)	Moderate	Reduced vitamin D receptor sensitivity. Higher vitamin D intake recommended (2000-4000 IU/day).