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Hypothalamic leptin signaling.
Leptin receptor variant affecting hypothalamic sensitivity to leptin satiety signals. Influences how effectively the brain reads fullness signals from fat tissue. Relevant complement to FTO rs9939609 for appetite regulation.
| Genotype | Impact | What it means |
|---|---|---|
| AA (Normal) | Normal | Normal leptin receptor sensitivity. Standard appetite and satiety hormonal signalling. Standard dietary and portion recommendations apply. |
| AG (Carrier) | Low impact | Mildly altered leptin signalling dynamics. Slightly reduced satiety response to circulating leptin. Higher protein intake and regular structured meal timing may help maintain satiety. |
| GG (Variant) | Moderate | Reduced leptin receptor sensitivity with more pronounced impaired satiety signalling. High-protein diet (1.6-2.0 g/kg), structured meal spacing, high dietary fibre, and avoidance of highly palatable processed foods are specifically beneficial. |
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